Reduction in lesions from Lmax : a new concept for assessing efficacy of field - directed therapy for actinic
نویسندگان
چکیده
1 Department of Dermatology, Charité – University Medical Centre Berlin, Charité Platz 1, Berlin, D-10117, Germany 2 Department of Dermatology, Monklands Hospital, Airdrie, Lanarkshire, ML6 0JS, UK 3 Department of Dermatology, University of L’Aquila, Via Vetoio Coppito 2, 67100 L’Aquila, Italy 4 Service de Dermatologie Allergologie, Hôpital Cochin, 89 rue d’Assas, 75006 Paris, France and Université Paris 5 Descartes, Paris, France 5 Meda Pharma GmbH & Co. KG, Benzstrasse 1, 61353 Bad Homburg, Germany 6 Department of Dermatology, Institut Universitari Dexeus, Av. Carles III 71-75, 8
منابع مشابه
Reduction in lesions from Lmax: a new concept for assessing efficacy of field-directed therapy for actinic keratosis. Results with imiquimod 3.75%.
BACKGROUND Current parameters for assessing the efficacy of actinic keratosis (AK) treatments compare clinical lesions at the start and end of a study. However, the sun-exposed field also contains subclinical lesions which may become detectable during treatment. Lmax, the maximum lesion count during treatment, is a new concept to better assess the efficacy of field-directed AK therapies. Measur...
متن کاملLong-term sustained lesion clearance from Lmax with imiquimod 3.75%, a new field-directed treatment for actinic keratosis.
BACKGROUND In patients with actinic keratosis (AK), subclinical and clinical lesions coexist across large areas of sun-exposed skin. The long-term efficacy of AK treatments depends on their ability to eradicate both types of lesions across the entire field. OBJECTIVE To assess the long-term efficacy of imiquimod 3.75% using the reduction in lesions from Lmax (maximum lesion count during treat...
متن کاملReduction in lesions from Lmax : a new concept for assessing efficacy
1 Department of Dermatology, Charité – University Medical Centre Berlin, Charité Platz 1, Berlin, D-10117, Germany 2 Department of Dermatology, Monklands Hospital, Airdrie, Lanarkshire, ML6 0JS, UK 3 Department of Dermatology, University of L’Aquila, Via Vetoio Coppito 2, 67100 L’Aquila, Italy 4 Service de Dermatologie Allergologie, Hôpital Cochin, 89 rue d’Assas, 75006 Paris, France and Univer...
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INTRODUCTION Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clinical guidelines recommend that all are treated. The objective of this study was to evaluate the efficacy and safety of 5-fluorouracil (5-FU) 0.5%/salicylic acid 10% as field-directed treatment of AK lesions. METHODS This multicenter, double-blind, vehicle-controlled study (NCT0...
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OBJECTIVE Cumulative exposure of the skin to ultraviolet radiation promotes mutation in keratinocytes and their abnormal growth led to the formation of scaly lesions, called actinic keratoses (AKs). Its incidence is growing at an emerging rate, becoming a worldwide problem especially for occupational ultraviolet (UV) rays exposure. Detectable lesions are often associated with field changes, wher...
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